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Further adverse events observed with tirzepatide treatment included sinus tachycardia associated with a concomitant increase from baseline in heart rate of 15 beats per minute (4.6%10.0% vs

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Furthermore, our study reveals that metformin can alleviate ECM degradation and inflammation in chondrocytes exposed to H 2 O 2 by reducing oxidative stress-induced damages Additionally, our results establish that metformin exerts its antioxidant effects mainly through the Nrf2 signaling pathway, ultimately slowing OA progression (Fig

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