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(Regulatory Toxicology and Pharmacology, 2020) reported a preclinical safety package designed to support potential drug development

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Furthermore, the tauopathy model THY-Tau22 has phosphorylated tau expression correlated with hippocampal dysfunction and anxiety-like phenotypes (Schindowski et al., 2006)

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Interestingly, high altitude hypoxia increases endoplasmic reticulum stress and oxidative stress (Himadri et al., 2010)