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Monitoring and assessing epitalon effectiveness Determining whether a protocol is working requires appropriate biomarkers and realistic expectations about timelines

Compared to graft biopsy of living donors, specimens of DBD were characterized by an increased transcriptional activation of complement components, acute-phase proteins and chemokines ( vs 4% when CIT was less than 16h at 1 year, 36% vs 20% at 10 years) ( Figure 2 Complement System in Renal Transplantation: Strategies of Inhibition in the Donor and During Preservation The activation of immune system plays a central role in all transplantation phases ( The stepwise process of transplantation consists of consecutive events that can affect the graft, including brain or cardiac death in deceased donors, unavoidable ischemia/reperfusion injury, preservation procedure, post-transplantation rejection and other non-immunological insults such as drug toxicity, diabetes or hypertension ( Complement has a critical role in immunological and inflammatory processes before, during and after transplantation