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Rather than inefficiently conducting bespoke analyses one-question-one-method-one-database-at-a-time, leaving us vulnerable to various threats to scientific validity, LEGEND provides a systematic framework that can reproducibly generate evidence by applying advanced analytics across a network of disparate databases for a wide array of exposures and outcomes. VIDEO : OHDSI collaborators discuss LEGEND Not only does LEGEND offer a path to scale to the real needs of the health care community, Ryan added, it also provides the complementary diagnostics to help us understand how much we can trust the evidence weve produced. About the Study The study was developed through tools and best practices set by the OHDSI network, a multi-stakeholder, interdisciplinary collaborative to bring out the value of health data through large-scale analytics