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Protein helps preserve muscle mass during weight loss, while fiber promotes healthy digestion and blood sugar regulation

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Mesolimbic reward system : The ventral tegmental area (VTA) and nucleus accumbens express GLP-1 receptors, positioning GLP-1 to modulate dopaminergic reward pathways that influence food reward and potentially addictive behaviors

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Food intake, hydration, fiber, activity, other medications, and baseline bowel habits may all be relevant

Specifically, retatrutide targets the following receptors: GLP-1 (glucagon-like peptide-1) GIP (glucose-dependent insulinotropic polypeptide) Glucagon These hormones help regulate hunger, blood sugar and energy use