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59 Chemerin induces placental inflammation by recruiting macrophages and promoting the release of interleukin-18 and interleukin-1, thereby downregulating miR-140-3p and miR-574-3p expression and contributing to placental dysfunction in GDM

These effects are initially mediated by natriuresis and plasma volume contraction, but sustained effects likely reflect additional mechanisms including reduced total body sodium, decrease in intracellular sodium and calcium, and vasodilation

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