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The presence of primary cilia on islet cells is conserved across species (13) and has been shown to be critical for signaling of specific GPCRs to regulate islet insulin and glucagon secretion (14)

What SURMOUNT-5 revealed is a meaningful difference in how often those side effects cause patients to stop treatment: GI-related discontinuation was 2.7% with tirzepatide vs

These agents are extensively utilized in managing T2DM and obesity and have demonstrated efficacy in reducing nonfatal myocardial infarction, stroke, and mortality in affected patients