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doi: 10.1016/j.immuni.2011.09.021 137 MetzlerBGfellerPGuinetE

However, this is usually costly

Hepatologists are not typically the primary providers managing chronic pain, but clinicians from other specialties may be less familiar with analgesic safety in the setting of liver dysfunction [126]

Vitamin overdoses may increase unwanted side effects

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That distinct mechanism is exactly why it is discussed as a complement to GLP-1 or GIP/GLP-1 agonists rather than a substitute