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The brain is extremely sensitive to changes in fluid and sodium balance

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20 The decision on which agent to recommend will largely be dictated by individual factors such as co-morbidity and renal function

Also, a phase 2 trial that aims to evaluate the effect of sustained-release formulation of exenatide in symptom improvement in PD, is under way (NCT04269642, Table 2), as well as a dose-ranging trial on the efficacy of pegylated form of exenatide in PD-related motor symptom progression (NCT04154072, Table 2)

For example, semaglutide can lead to better blood flow, which can help organs like the heart and kidneys

injection of d-glucose (1 or 2 g kg 1 , 10 ml kg 1 ), insulin (1.0 or 1.5 IU kg 1 , 10 ml kg 1 ) or sodium pyruvate (2 g kg 1 , 10 ml kg 1 ), and blood samples were collected at 15240 min