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The burden of proof shifts
When activated, it switches on genes for mitochondrial biogenesis, oxidative phosphorylation, the TCA cycle, and fatty acid -oxidation
Heliyon 8 (11), e11411
Preclinical evidence links MOTS-c to reduced myostatin signaling - myostatin is the protein that limits muscle growth, so less of it makes it easier to keep muscle during a deficit
Increased cell shrinkage, loss of cellular adhesions, and apoptotic bodies were observed in treated HeLa cells
Articles Source Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., & Kolega, Z
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