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While weight cycling (repeated loss and regain) has some negative health associations, these are primarily correlation, not proven causation

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Moreover, any significant or unexplained changes in your weight, appetite, or general health should be discussed with your healthcare provider to determine if adjustments to your treatment plan are necessary

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When the medication is removed, individuals may not have established the behavioral skills necessary to maintain weight loss independently, leading to a return to previous eating patterns that originally contributed to weight gain