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The efficacy and safety of different GLP-1 RAs were also explored
Developed as a glucagon-like peptide-1 (GLP-1) agonist, semaglutide works by enhancing insulin secretion, thereby reducing blood sugar levels
This aims to enhance access to GLP-1 medications for individuals enrolled in Medicare and Medicaid
They also made specific amino acid substitutions that provide resistance to DPP-4, an enzyme that rapidly degrades natural GLP-1
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That practicality is part of why it has held up as a first-line option for so long
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