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[4] [5] Bowel obstruction : Severe, cramping abdominal pain, absolute constipation (no passage of stool or wind), progressive abdominal distension, and vomiting require urgent evaluation

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(2) The action characteristics of various types of non-insulin hypoglycemic drugs are compared, as well as the advantages, shortcomings, points for attention and challenges of GLP-1RAs in treatment

The challenge has been highlighted most recently by the US Food and Drug Administrations approval of higherdose Wegovy, which provides increased weight loss but is associated with higher rates of gastrointestinal complaints, particularly nausea and vomiting

If side effects persist beyond the first 2-4 weeks at a given dose, dose reduction or slower titration may be warranted rather than discontinuation

Which drug is better for type 2 diabetes and obesity together