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Taken together, we propose that in HF enhanced activation of afferent renal nerves leads to enhanced activation of efferent renal sympathetic nerves response to GLP-1 possibly via central nervous system, thereby suppressing diuresis and natriuresis (Fig

Figure 2 Inhibition of GLS leads to increased intracellular Gln, decreased Glu, and decreased intracellular levels of a-KG ( Figure 2 ) ( in vivo , impairs Th1 induction, and attenuates inflammatory T-cell responses (49)