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The study reported that tolerance at this dose was similar to placebo

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Although our results highlight exendin 2029 as a promising candidate for developing safer peptide analgesics targeting TRPV1, the translation of these findings into clinical practice requires further investigation

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586,587 Similarly, reactive astrocytes are associated with -amyloid deposits in the brains of various transgenic AD models (most of which are models of hyperamyloidosis), although sometimes reactive remodelling of astrocytes precedes formation of -amyloid plaques