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Significantly, melatonin supplementation has demonstrated the capacity to alleviate oxidative stress and impede the accumulation of A, as well as tau hyperphosphorylation, in the hippocampus of aged rats exhibiting brain insulin resistance induced by a high-fat diet [135]

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Fatty acyl-CoA is then metabolized through -oxidation in the mitochondrial matrix, ultimately yielding propionyl-CoA and acetyl-CoA (6)

Uroprotective effect of ambroxol in cyclophosphamide-induced cystitis in mice