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Originally designed to help manage type 2 diabetes, GLP-1 receptor agonists have gained widespread attention for another reason: their ability to support significant, sustained weight loss
August, A
[PMID: 8921832] PubMed record related to this compound for laboratory literature review
Researchers still would not know where that effect comes from: weight loss itself, broader improvement in metabolic function, or a more direct effect on inflammation, the immune system or tumors
However, the hyperglycemic effects of glucagon pose a challenge for its therapeutic application [77]
Earlier Phase II data also showed weight reductions approaching 24%
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