Summarizing all studies, Sarlis et al
By competitively binding to p53, FOXO4-DRI displaces endogenous FOXO4, causing p53 nuclear exclusion and translocation to mitochondria where it triggers the intrinsic apoptotic pathway through caspase-3/7 activation
This latter benefit may make it possible to more adequately treat psychiatric conditions, which are notoriously difficult to treat, in part because patients often discontinue their medications secondary to severe side effects
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How Much Weight Loss Can You Expect with GLP-1 Treatment
Brauer R, Wei L, Ma T, Arah OA, Nielsen J, Mellemkjaer L, et al