Mechanistically, we found that insufficiency of vitamin B 12 during OSKM reprogramming resulted in changes in the bulk levels of many histone methylation marks, including a failure to properly trimethylate H3K36 at transcribed gene bodies, leading to increased levels of CT
Why do we need B12 to be made OTC
80 L of each plasma sample is transferred to previously prepared tubes containing 240 L of ice-cold acetonitrile and vortexed vigorously
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