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For most, these side effects ease over time, but when they linger, they can feel draining

Maximus provides general health optimization services, including GLP-1 medications, as part of their broader healthcare platform

Carnitine depletion can also result in intracellular accumulation of toxic acyl-CoA, resulting in impairment in several enzymatic processes (-ketoacid oxidation and gluconeogenesis, among others)

Beyond the framework of diet and exercise, staying hydrated and getting enough rest are crucial aspects that shouldn't be overlooked

This GLP-1 and GIP receptor agonist slows gastric emptying to improve glycaemic control, but this mechanism can also reduce bowel motility and increase water reabsorption in the colon, leading to harder stools

Funding This work was supported by National Natural Science Foundation of China (82000602) and Knowledge Innovation Program of Wuhan-Shuguang Project (2022020801020448)