Dont fall for the company line of better water solubility yields better bioavailability
Due to insufficient NADPH, G6PD-deficiency leads to a switch of the biosynthetic pathway for GSH, thus limiting AMPK activation (62)
But we don't live in an ideal world
Gradually increase to 1 mg, then 1.7 mg, and finally reach the maintenance dose of 2.4 mg by week 17
Beginners typically start with 0.5-1mg administered subcutaneously 3-5 times per week
Evidence-based endometriosis treatments include hormonal therapies such as combined oral contraceptives, progestins, GnRH agonists, and GnRH antagonists (elagolix, relugolix combination), along with NSAIDs for pain management