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Protects Kidney Function GLP-1s are generally kidney-protective
Until recently, glycemic control, blood pressure management, angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARB) were the only available strategies to prevent diabetic kidney disease (DKD) progression
doi:10.1111/j.1472-765X.2007.02276.x
It activates AMPK - the cellular energy sensor that flips muscle cells from preferring glucose to preferring fat as fuel
Retatrutide is the lead candidate and remains investigational
"Our preliminary data suggest that GLP-1s suppress intake through a different mechanism," DiFeliceantonio said
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