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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

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In Vivo Studies and Potential Therapies Several DS mouse models have been developed to study the neurobiological and cognitive impairment mechanisms implicated in T21 (Gupta, Dhanasekaran, and Gardiner 2016

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