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Cell 133 , 235249 (2008)

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This modified 1-29 amino acid GHRH analog has improved bioavailability over Sermorelin, but still only lasts about 30 minutes in the bloodstream

Early studies demonstrated that Ipamorelin effectively activated the growth hormone secretagogue receptor (GHS-R1a), resulting in increased growth hormone secretion through ghrelin-related signaling mechanisms