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Johns Hopkins Medicine

On April 15, the FDA published a notice scheduling a meeting of the Pharmacy Compounding Advisory Committee (PCAC) for July 2324, 2026, at which the committee will consider whether to recommend certain peptide bulk drug substances for inclusion on the 503A bulks list

Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ, Michelson EL, Olofsson B, Ostergren J, Yusuf S, Pocock S

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Then, in 2015, Lee and colleagues identified a previously overlooked open reading frame within the 12S ribosomal RNA gene of mtDNA and found that it encodes a functional peptide, MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) [1]

This makes them more likely to have a B12 deficiency