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The clinical evidence Semaglutide and tirzepatide have been studied in large, NEJM-published trials of the FDA-approved branded formulations

Phentermine may be the better choice if: You need to lose a moderate amount of weight (10-20 pounds)

Many patients find liquid proteins like smoothies easier to consume due to semaglutide's early satiety effects

The FDA's December 22, 2025 approval of the first oral GLP-1 for obesity marks an inflection point in treatment options

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Aim for 3-4 resistance training sessions per week, focusing on compound movements that work multiple muscle groups: squats, deadlifts, presses, rows, and pull-ups