Vitamin C helps "recharge" glutathione after it has neutralized a free radical, turning it back into its active "reduced" form
The latter may be caused by intestinal disorders, infections, bariatric surgery, or pharmacological interference, including histamine H2 receptor antagonists and metformin
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It is not a cosmetic ingredient, not a drug, and is not supplied for human application
They also carry the risks inherent to any surgical procedure, require recovery time, and demand lifelong nutritional follow-up
A notable double-blind RCT in 262 elderly subjects found that NAC (600 mg twice daily) for 6 months significantly reduced influenza-like episodes only 25% of NAC-treated subjects who seroconverted to influenza A developed clinical symptoms, compared to 79% of placebo subjects (De Flora et al., Eur Respir J, 1997) [40]