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Unlike traditional GLP-1 agonists that target a single receptor pathway, tirzepatide simultaneously activates both GLP-1 and glucose-dependent insulinotropic peptide (GIP) receptors

Fermentable fiber foods such as Brussels sprouts, black beans, lentils, split peas, oats, and raspberries stimulate the gut to secrete GLP-1 peptides

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Because retreatment effects were applied before outcomes fully returned to baseline, it is theoretically possible that BMI could decline further with repeated courses

Answer fully and honestly the assessment only protects you if it is complete

The Phase 2 MASH trial (published in NEJM) This 48-week randomized, double-blind, placebo-controlled trial enrolled 293 adults with biopsy-confirmed MASH and fibrosis stages F1 through F3