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These data points suggest that GLP-1 receptor activation itself, rather than any semaglutide-specific property, may be responsible for the allodynia risk

There are discrepancies in the T max values between the experimental data and the model simulations for the PO dataset

Understanding these mechanisms helps clinicians determine whether the elevation is benign or indicative of significant pathology

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Additionally, GLP-1 receptors have been identified in various tissues involved in inflammation and immune regulation, raising questions about potential anti-inflammatory effects that could theoretically benefit the chronic inflammatory component of lymphedema