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Additional information Peer review information Nature Microbiology thanks Marc Donath, Lesley Hoyles and Liping Zhao for their contribution to the peer review of this work

Both MK-801 and GLP-1 have been linked to improvements in glucose homeostasis in mice 20,21

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Currently, in vivo brain markers in AD and MCI mainly include positron emission tomography scanning of amyloid, tau, and glucose metabolism, as well as brain structural imaging using MRI such as hippocampal atrophy [81]

Colonic motility decreases