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AdamsJBAudhyaTGeisEGehnEFimbresVPollardELet al

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A 94 (4), 15001505

This modification enhances its biological activity, resulting in a higher affinity for the IGF-1 receptor and a lower affinity for IGF-binding proteins compared to endogenous IGF-1

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In addition, the protective effects of both a recombinant adiponectin injection in ob/ob mice and metformin administration against NAFLD have been attributed, at least in part, to the inhibition of hepatic TNF expression 24,25