Diabetes metabolism J 45(5):641654 Fernndez-Snchez A, Madrigal-Santilln E, Bautista M et al (2011) Inflammation, oxidative stress, and obesity
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Docking studies revealed that compounds with aromatic amine residues interact with the large pocket of DPP-4, while compounds with cyclic secondary amine residues bind in the small pocket, similar to Vildagliptin
The copper ion is chelated primarily through the imidazole nitrogen of histidine and the alpha-amino nitrogen of glycine, creating a stable, biologically active complex