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When used for insulin, 1 unit equals 1 international unit of insulin because insulin is formulated at 100 IU per mL

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The first dose is usually 1000 mcg (1 mg)

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Loading protocol (optional, not generally recommended for people with type 2 diabetes): 20 grams per day, divided into 4 doses of 5 grams each Duration: 57 days This rapidly saturates muscle creatine stores but may increase the risk of gastrointestinal side effects and water retention Maintenance dose (recommended approach for people with type 2 diabetes): 3 grams per day as a single dose This achieves muscle saturation more gradually (typically within 34 weeks) Generally better tolerated and equally effective over time Allows for careful monitoring of any effects on blood glucose levels or medication requirements For people with diabetes, starting with 3 grams daily without a loading phase is the most prudent approach, as it minimises potential side effects and allows for careful monitoring

Gigliotti L, Warshaw H, Evert A, et al