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While Metformin improves insulin sensitivity and helps control appetite, GLP-1 medications (like semaglutide or tirzepatide) slow digestion and enhance feelings of fullness
Elevated levels of pro-inflammatory cytokines, such as Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-), generate massive amounts of reactive oxygen species (ROS)
Semaglutide has been associated with nausea, dizziness, and headaches, which may indirectly affect the ears or balance, but direct ear-related side effects are uncommon
Your provider should document your starting dose and titration history to ensure continuity of care
Weight stabilisation not constant reduction is expected once the body reaches a new equilibrium
They should be carefully administered to patients with risks of hypovolemia (older age, cardiovascular diseases, treatment with diuretics, liver cirrhosis with circulatory dysfunction)
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