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It activates the GIP receptor with approximately equal potency to native GIP, but activates the GLP-1 receptor with roughly five times lower potency than native GLP-1

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In a study on hepatocellular carcinoma (HCC), Zip2 and Zip9 were upregulated in M2-polarized macrophages, while Zip9 was slightly downregulated in M1-polarized macrophages