Only features with metabolite identifications were considered for statistical analyses
Chen W, Wang Y, Pan Z, Chen X, Luo D, Wang H
Concentration-wise, this ingredient is rarely used pure and usually shows up as part of a standardized centella extract where reported content ranges from 0.02-3.06%
This may affect tissue distribution or copper binding of the peptide
Nevertheless, this theoretical concern means PTD-DBM should not be used by individuals with active or recent history of Wnt-pathway-associated cancers, particularly skin cancers in the treatment area
fragment-specific activity review: PMC8724243 TB-4 / TB-500 product mislabeling documented bidirectional mislabeling between full-length TB-4 (43 aa) and the TB-500 fragment (residues 1723) in marketed peptide products: Esposito M et al