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In a healthy body, dietary folate is converted through a series of enzymatic steps into its biologically active form, L-5-methyltetrahydrofolate (L-5-MTHF)

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Both cross the bloodbrain barrier and have been shown to lower nighttime cortisol by dampening the hypothalamicpituitaryadrenal (HPA) axis, which in turn reduces stressinduced awakenings

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