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Nutr Diabetes (2013) 3(6):e78

Both undernutrition and obesity can disrupt this axis

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While no scientific studies have compared pharmaceutical drugs with supplements, a healthy diet including nutrient-dense foods and regular physical activity plays a vital role in weight management

These drugs were chosen because they represent different modes of action: paclitaxel and vincristine are microtubule-targeting agents, cisplatin forms covalent bonds with DNA and by that causes intra-strand and inter-strand cross-links that interfere with DNA replication and transcription, and doxorubicin intercalates into DNA and inhibiting topoisomerase II