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doi: 10.1016/j.cell.2012.03.042 2 LiZChenLChenCZhouYHuDYangJet al

Involvement of hydrogen peroxide (H 2 O 2 ) is well known for induction of necrosis

JAMA 2014

In post-marketing experience, angioedema and angioedema-like reactions were reported with parenteral methylcobalamin

Non-Vascular Approach: Offers a safe alternative for those who may have contraindications with traditional vasodilator medications

[16] [18] Current clinical guidelines recommend caution and individualized decision-making, given the lack of robust safety data for high-dose injectable vitamin C in pregnancy and lactation