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Changes in fluid intake, fiber, activity, other medications, and pre-existing bowel patterns can affect symptoms

The fact that blocking GLP-1 receptors has been shown to correct PPHG after gastric bypass highlights the significance of GLP-1

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This means they took patients who previously took metformin but didnt lose ANY weight, and they put these patients on the combination of metformin plus GLP-1 agonist and they did, in fact, lose weight