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This study utilized a CASSCF approach to demonstrate that while all forms of vitamin B12 interact with glutathione, NADPH, FMN, and FAD by breaking Co-C or Co-O bonds and facilitating electron transfer, only glutathione effectively converts cyanocobalamin into a biologically active form, aligning with clinical observations

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Its experimental effects reflect combined actions on vascular regulation, inflammatory balance, cellular protection, and structural remodeling, collectively supporting tissue adaptation and recovery under stress conditions

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