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Many patients begin noticing changes in energy and appetite regulation within weeks

Research from the Kinsey Institute published in 2025 showed mixed results among GLP-1 users

The BMS guidance did not say by how much the dose of oral progestogen should be increased a document published by the Primary Care Womens Health Society (PCWHS) suggested that a pragmatic approach would be to use the same increases as we would use for women taking a higher than usual dose of oestrogen, but also pointed out that the lack of data to guide this and emphasised that the levonorgestrel intrauterine device gives the best endometrial protection and should be recommended in this situation

The therapys prescribing information has a boxed warning for the risk of thyroid C-cell tumors, such as medullary thyroid carcinoma (MTC)

The following immunosuppressive agents may be considered as well: tacrolimus, mycophenolate mofetil and thalidomide