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It is specifically contraindicated for individuals with: A personal or family history of medullary thyroid carcinoma (MTC), based on findings of thyroid C-cell tumours in animal studies Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Type 1 diabetes or diabetic ketoacidosis semaglutide is not designed for this purpose Pregnancy, or plans to become pregnant within the next 2 months (semaglutide should be discontinued at least 2 months before attempting conception) Age under 12 years (Wegovy is approved from age 12 only for severe obesity, under specialist supervision) Additional caution is needed for patients with a history of pancreatitis, gallbladder disease, diabetic retinopathy, or significant kidney impairment these patients require closer monitoring throughout treatment
The brain is extremely sensitive to electrolyte imbalances
BMC Pharmacol Toxicol
Potential cardiovascular benefits
As they dissolve, hormones are gradually absorbed into the bloodstream
Nauck MA, Niedereichholz U, Ettler R, et al
