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High-dose treatments may give faster results, while lower doses are gentler and safer for maintenance

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Early data also suggest improvements in liver fat and cardiovascular markers, positioning retatrutide as a potential treatment for nonalcoholic steatohepatitis (NASH) (Zhou et al., 2023)

Lang F, Gulbins E, Lang PA, Zappulla D, Fller M

Importantly, not all variants confer increased risk: loss of function variants in HSD17B13, a lipid droplet-associated protein in hepatocytes, have been consistently associated with reduced hepatic inflammation and a lower risk of fibrosis and advanced liver disease [16]

Consequently, several studies have focused on developing benchmark resources [6, 30, 62, 68]