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72-week results in adults with obesity (BMI 30), without diabetes

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Derosa et al., 2025)

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Each of these is a red flag

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Regulatory and quality concerns : Enema equipment may fall under MHRA medical device regulations, but coffee solutions are not licensed medicines

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Patients on semaglutide 0.5 mg lost a mean of 4.6 kg versus 2.3 kg with dulaglutide 0.75 mg

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however, subsequent evidence indicates that most GLP-1mediated hepatic effects are indirect, driven by reductions in caloric intake, body weight, and insulin resistance [77]

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