when did glp-1 come out A timeline of GLP- 1 discovery and clinical development. Created in Evolution of GLP‐1 Receptor Agonists

These early seizures may be related to early subcortical white matter involvement, and similarly, severe subcortical involvement may be associated with recurrent generalized tonic-clonic seizures [50]

While oxidative stress affects the brain, there's no silver bullet

both GLP-1 receptor agonists were superior in reducing motor impairments compared to exenatide [85]

10.1016/S0140-6736(19)31271-1 Summary Keywords colorectal cancer, gastrointestinal cancer, GLP-1 receptor agonists, liver cancer, meta-analysis, obesity, oncological safety, pancreatic cancer Citation Wali AF, Rangraze I, Khan S, Mufti UB, El-Tanani M and Rizzo M (2026) Reassessing cancer risk with GLP-1 receptor agonists: a comprehensive meta-analysis of gastrointestinal malignancies

124 The dual GLP-1/GIP receptor agonist tirzepatide ameliorated AD pathology in diabetic rat models by improving learning and memory, modulating cerebral glucose metabolism, promoting neurotrophic factor expression, and suppressing inflammatory responses

Naltrexone HCl and bupropion (Contrave) Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formula