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Key Takeaways The condition progresses through three distinct phases: freezing (2-9 months of increasing pain), frozen (4-12 months of severe stiffness with less pain), and thawing (5-24 months of gradual mobility return)

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For GHK-Cu, the best-supported claims come from topical and wound-related evidence, while injectable and systemic claims need more rigorous human data [2], [3], [8]

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