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Most patients begin with 0.25 mg weekly for four weeks as an initiation dose (not intended for glycaemic control), increasing to 0.5 mg, and potentially up to 1 mg or 2 mg depending on glycaemic targets and tolerability

As opposed to the small population of GLP1-expressing endocrine cells, the fact that a large part of the pancreatic acinar population expresses GLP1R, even in low density, indicates that there is a considerable amount of nonendocrine GLP1R in the pancreas, for which a physiological role is not yet known

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