It binds to GLP-1 receptors in your brain, pancreas, and digestive tract, helping to reduce appetite, slow digestion, and regulate blood sugar, but in a way thats stronger and longer-lasting than your bodys own GLP-1 response
Benefits can include: Lower blood pressure Lower total cholesterol Better liver health for those with metabolic dysfunctionassociated steatotic liver disease (MASLD) Lower blood sugar and reduced diabetes risk Lower risk of kidney disease Tirzepatide and orforglipron are newer drugs that dont yet have results from long-term cardiovascular health trials
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STEP-2 - 1.0 mg vs 2.4 mg dose comparison
A pre-specified meta-analysis of seven SURPASS trials demonstrated that tirzepatide was not inferior to placebo or active comparators, including insulin glargine, insulin degludec, semaglutide, and dulaglutide, in major adverse cardiovascular event (MACE) reduction [7]
Taking tirzepatide a day early is generally acceptable as long as you maintain roughly seven-day intervals going forward