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Fatigue or feeling cold during fast weight loss Fewer cravings for alcohol, snacks, or junk food (commonly reported) When to Slow Down or Stop Vomiting that does not stop within 24 hours Severe upper abdominal pain that wraps around to the back Yellowing of skin or eyes Severe dehydration signs (dizziness, very dark urine, racing heart) Rapid weight loss over 2 lb per week sustained for many weeks (lean tissue loss risk) 13

Idiosyncratic (type B) injury occurs without warning, when agents cause non-predictable hepatotoxicity in susceptible individuals, which is not related to dose and has a variable latency period

The HIF pathway and erythrocytosis

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